Oh et al., 1999; Watanabe et al., 1999). In rats subjected to MCAO, the results of an IP receptor ligand (15-deoxy-TIC) created to bind the IP2 receptor was discovered to be considerably neuroprotective compared using the peripheral kind IP receptor ligand, iloprost methylester, administered 24 h after ischemia (Takamatsu et al., 2002). From proof supporting the neuroprotective role of IP receptor